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About this article Cite this article Ran, L., Zhao, R., Hu, G

And this point is relevant as TMAO is excreted by the kidneys, and so damaged kidneys cannot excrete TMAO effectively

16 AzziA.ZinggJ.-M

[200] [199] Depending on the protein kinase involved and the residue(s) phosphorylated, phosphorylation can shift transporter function into an efflux-permissive state that causes the reverse transport of cytosolic monoamines into the synaptic cleft, or it can promote transporter internalization, whereby phosphorylated transporters are withdrawn from the plasma membrane and lower total reuptake capacity (i.e., non-competitive reuptake inhibition)