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Acknowledgements The authors would like to thank Martin Balcerowicz and Marino Exposito-Rodriguez for their helpful comments on the manuscript

small aliquots stored at lower temperatures extend usable life

Long-Term Intervention with Pravastatin in Ischaemic Disease Study Group, 1998

With MD simulations of reasonable quality and in agreement with the protein dynamics in solution on the microsecond timescale, it becomes meaningful to use the MD ensembles to study the effects induced by phosphorylation and unveil new details of the underlying mechanism