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Sci Rep 6 , 21162, doi:10.1038/srep21162 (2016)

Notably, previous studies have shown that Ercc2 gene expression was increased in the brains of individuals with Down Syndrome (DS) 116 , while XPD protein expression was increased in the brains of individuals with DS and AD 117

Combining them aims to calm inflammatory activity while supporting repair of the lining, which is why the stack is described as dual-action rather than a single mechanism