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Eur Urol 50:141147

Research shows that CML cells with the BCR-ABL-T315I mutation treated with AKI603 display features typical of senescent cells, such as increased SA--Gal activity, altered morphology, elevated levels of p53, p21, p27, and p16, as well as SASP secretion [79]

Typical cycle: 812 weeks on, then 24 weeks off

Whether biopsy tissue is best obtained by endoscopy (partial thickness, limited access) as in Figure 7 or laparotomy (full thickness, unlimited access) is the focus of a number of recent publications, much historical debate, and is not a simple question to answer