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However, due to the absence of centrioles, the resultant spindle morphology is reduced in size, and the characteristic astral microtubules at the poles are absent, contributing to the increased instability of spindle assembly in human oocytes

For the trial product estimand, continuous endpoint analyses were conducted using a mixed model for repeated measures with randomized treatment as a factor and baseline endpoint value as a covariate

Disruption of the classic sleep/wake cycle is commonly caused by staying awake due to work or lifestyle choices (Boivin and Boudreau, 2004, The innate need for sleep is seen throughout evolution (Miyazaki et al., 2017) and its absence can cause a wide range of disturbances throughout the body

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