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Dysregulation of TLRs plays an important role in the development of AD, particularly in the early stages of the disease, by affecting synaptic plasticity, microglial activity, phosphorylation, and inflammatory responses (Momtazmanesh et al., 2020)

In the United States, for example, the Bureau of Alcohol, Tobacco, Firearms and Explosives devotes a paltry 2 percent of its personnel and budget to tobacco programs

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