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The mice recapitulate human NASH transcriptome and metabolome profiles and reveal a translational histopathology in the liver with steatosis, inflammatory aggregates and bridging fibrosis, as well as atherosclerosis development

A lossoffunction library will be used to find genes whose knockout reactivates MHCII, while a CRISPRa library will pinpoint activators capable of restoring antigen presentation

Assay Type: Enzyme Activity kit Sample Types: Serum, Plasma, RBCs and Cell Lysates Sensitivity: 0.009 mU/mL Standard Curve Range: 0.15 mU/mL5 mU/mL Specifications Specifications For Research Use Only