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Similarities between the two have been pointed out, such as the mysterious, enigmatic nature they share, the references to smoking present in Half-Life: Alyx , and spoken lines themselves, G-Man's infamous line "Prepare for unforeseen consequences" bearing a slight resemblance to the Smoking Man's line "There have been unforeseen events"

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Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2,5-dimethypyrazine