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Reward-enhancing effects of d-amphetamine and its interactions with nicotine were greater in female rats and persisted across schedules of reinforcement

While some of this reduction can be attributed to changes in smoking behaviour that preceded CTCP, a substantial fraction has been associated with CTCP's efforts.57 A similar accelerated decline was identified for heart disease.58 These changes in smoking behaviour resulted in an estimated $86 billion reduction in healthcare costs between 1989 and 2004.57 Changes in smoking behaviour over the last half century have left behind a residual smoking population that is disproportionately composed of less advantaged groups, raising the questions of whether tobacco control efforts are reaching or are effective for these populations