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(2002) and Maquart et al

Four subgroups were defined according to the patient's baseline status, including those with normal kidney function, reduced kidney function, selenium deficiency, and submaximal GPx3 activity

That said, dosages up to 1,200 milligrams per day have been studied with no serious adverse effects reported. However, there isnt much long-term research with high doses of NMN, according to Jillian