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Steurer, M

doi: 10.1038/nrc.2016.108

In adipose and ovarian tissues, macrophages are abnormally activated and polarized toward a pro-inflammatory (M1) phenotype, secreting IL-6, TNF-, and other factors that exacerbate local and systemic inflammation and insulin resistance, potentially interfering with follicular development (18)

In particular, bacterial species can contribute either directly or indirectly to cancer initiation and/or progression, by mechanisms ranging from the production of toxins and dietary metabolites to biofilm formation and inhibition of anti-tumoral immune responses [64]