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doi: 10.1038/s42255-019-0043-x 6 CherestH.ThomasD.Surdin-KerjanY

Consistent with this observation, PERMANOVA analysis demonstrated no statistically significant difference between pre- and post-intervention metabolomes (F = 0.2135, R = 0.0117, p = 0.857), suggesting that the GF-MKD did not induce large-scale global metabolic remodeling

In addition, miR-155 downregulates STAT3 and SOCS1 in mouse macrophages, resulting in the upregulation of pro-inflammatory cytokines TNF and IL-1b and the downregulation of anti-inflammatory cytokine IL-10 [41]

The length of ICU stays and the need for endotracheal intubation in the LC group were significantly less than in the control group ( P 0.05, Table 1)