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MATERIALS AND METHODS Formalin-induced nociceptive behavioral test The time-effect curves of the control, morphine, and BPC-157 (from 10 to 40 g/kg) groups for the flinching response in the formalin test are shown in Figure 1

Phase 1: Activation (Weeks 14) Dose: Daily GHK-Cu activates collagen production while its copper component enables proper structural cross-linking BPC-157 builds the network of small blood vessels needed to feed active tissue TB-4 mobilizes and organizes repair cells KPV simultaneously suppresses inflammatory interference Expected: Skin hydration improves, tone evens, texture softens, redness decreases

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doi: 10.1016/0014-5793(88)80509-x