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As suggested above and in figure 1, the methionine cycle and the transsulfuration pathway influence homocysteine concentration and for this reason they are important research targets: The formation of methionine from homocysteine is essential to reduce the risk of homocysteine toxicity, conserve methionine as a substrate for protein synthesis, and produce a principle methylating agent in the form of SAM

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doi: 10.1007/s00018-006-6256-7 51 StollSWZhaoXElderJT

In a 3D culture format using human biopsy-derived ileal organoids and colonoids, differentiated organoids showed PXR-mediated induction of CYP3A4 expression, a response that is largely absent in parental Caco-2 cells 58