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Severe tears requiring surgery represent a different situation where peptides might support post-surgical healing rather than replacing surgical intervention

In this pathology, IGF-I levels diverge between studies, from increased to decreased IGF-I concentrations[330332], probably due to differences in samples origin (serum/cerebrospinal fluid vs spinal cord/musculoskeletal) and could be explained as a physiological defensive mechanism promoted in response to the neural degeneration and/or muscle atrophy

Neurochem Int 174:105698 Barjot C, Tournaire M, Castagnino C, Vigor C, Vercauteren J, Rossi JF(2007) Evaluation of antitumor effects of two vine stalk oligomers of resveratrol on a panel of lymphoid and myeloid cell lines: comparison with resveratrol

248 Drp1 is a fission-promoting protein