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(2016b) revealed that Tanshinone IIA mitigated the overactivity of glycogen synthase kinase (GSK)3, as well as the hyperactivation of its downstream mitogen-activated protein kinases, which are fundamentally involved in renal fibrogenesis and inflammatory processes

10.1097/00042737-199910000-00002 108 UysJ

Finally, knocking down ferroptosis suppressors sensitized cells to Fento-1, whereas knocking down Cd44 conferred a protective effect (Extended Data Fig