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For example, in the male reproductive system, melatonin can inhibit the expression of key steroidogenic genes (such as p450scc, p450c17, and StAR) in Leydig cells via MT1 receptors, thereby reducing testosterone synthesis (66) to inhibit sexual maturation, spontaneous ovulation, and the estrous response (67)

Management generally lasts for up to 8 h, depending on the indication, and may be accomplished 1 to 3 times on a daily basis [32]

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725 A randomized clinical trial has found that intravenous administration of the iron-chelating agent DFO reduces systemic iron levels and may have long-term efficacy in patients with ischemic stroke