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As an example, in mouse models of inflammatory arthritis, disruption of the molecular clock both in vivo, by constant light and genetic approaches, and in vitro, by pharmacological manipulation, altered clock gene expression in the joints, exacerbated joint inflammation, and enhanced arthritis score, thus indicating a direct role of the clock in disease progression 127

It implicated they may share different protein structure, so we performed protein structure prediction of CmEgt1 with I-Tasser to figure out the problem

These effects on inflammation and bone resorption have been demonstrated in rats with experimental periodontitis

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