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& Rios-Santos, F

The resulting myelin loss and reduced axonal density impede neural signal transmission, precipitating cognitive decline and driving the onset and progression of VCI

Phosphodiesterase 5 (PDE5) inhibitors have powerful protective effects against diabetic cardiomyopathy, and this may be dependent on H 2 S generation ( via promoting cardiac H 2 S biosynthesis and subsequent prevention of cardiomyocyte pyroptosis (Kar et al., 2019b)