melanotan and melanoma This one's not new, but it's back on my feed apparently back on yours too, so here we are. Melanoton II (AKA the "Barbie Drug") promises a tan without the sun Five primary melanomas in situ

Extracellular glutamate is cleared by a family of Na + -dependent transporters

In recent years, many ferroptosis inducers and inhibitors have been developed by regulating cellular lipid peroxidation across diverse tumor-related models, aiming to assess their impact on tumor cells as well as the immune cells within the tumor microenvironment

Free Radical Biol Med (2010) 49(9):132841

What they found: Plasma NAD+ did not rise directly , it was rapidly metabolized Plasma nicotinamide and methyl-nicotinamide rose markedly , markers of NAD+ metabolism NAD+ likely reaches tissues as its metabolites (not as whole NAD+) Clinically, patients subjectively reported increased energy during and after the infusion No serious adverse events during the 6-hour IV infusion Why it matters: The study provides rare clinical data on IV NAD+ , the administration route used by NAD+ clinics off-label