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GERD is associated with an increase frequency of COPD exacerbations [81]

The regulations address not only nicotine concentrations but also the chemical composition of e-liquids and the safety of the devices used

It is an interesting fact that in the largest coordinated enforcement effort in the FDAs history, the agency issued more than 1,300 warning letters and fines to retailers that illegally sold JUUL and other electronic cigarettes brands to minors.102 This phenomenon shows that there are substantial challenges involving the legal regulation and on-market monitoring of these products