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Receptors of GDF-15 are present in the appetite regulation site and when antibodies anti-GDF-15 were effective in controlling nausea and anorexia in some phase 1 clinical trials ( 2.2 Undernutrition and cancer Amid the most frequent conditions in paraneoplastic syndromes in cancer patients, cachexia stands out, characterized primarily by loss of muscle mass ( Dogs and cats with cancer-associated cachexia present reduced quality of life, response to treatment and a lower rate of disease remission when compared to patients who do not exhibit cachexia ( The metabolic changes caused by cancer also influence glucose utilization ( + ) ( According to Michael et al

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Dies wurde jedoch in der genannten Studie nicht nher untersucht