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Lancet 1991;338:131-7 American Academy of Pediatrics (AAP) Committee on Drugs

The interleukin-2 (IL-2)-dependent protein expression and CD38 association with CD16 on CD16 + NK cells are also central for the effector cytotoxic phenotype of lytic machinery [43]

Weight regain upon discontinuation is common with all GLP-1 therapies: Clinical data consistently show that weight regain occurs when GLP-1 receptor agonists are discontinued, typically recovering 50-75% of lost weight within 1-2 years