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Under normoxic conditions, HIF-1 is degraded via the ubiquitination pathway mediated by proteins such as prolyl hydroxylase domain (PHD) enzymes and the von HippelLindau (VHL) tumor suppressor protein

Quantitative determination of Bcl-2 in FACS-sorted normal and AML progenitor cells by laser scanning cytometry (LSC): Comparison with flow cytometry and Western blot analysis