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The plethora of structural information, together with the increasing power of computational facilities and refinement of binding prediction tools (110, 112, 119), open the possibility to design peptides/peptidomimetics able to target the translation complexes, with the aim to decrease protein synthesis of specific neuronal mRNAs and rescuing a healthy phenotype in individuals affected by FXS

10.1016/j.biopsych.2006.11.034 19 FanD.LiuL.WuZ.CaoM

A UV-Vis spectrophotometer was used to measure the concentration of free drug present in the collected supernatant

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