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When more than 40% of podocytes are damaged, it results in numerous dangerous side effects, including mesangial growth, adhesions, focal segmental glomerulosclerosis, or global sclerosis (211)

Mitochondrial dysfunction may further promote the release of Fe, intensifying the Fenton reaction and generating more OH, thereby amplifying intracellular oxidative stress

however, it important to highlight the condition since clinicians may need to request further investigation to determine its cause