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The medication does not instantly jump to ambient temperature the moment the ice packs give out

During infection or under stressful conditions, mature DCs present antigens to naive T cells, resulting in the differentiation of effector CD4 + T cells, production of B cell antibodies, and activation of macrophages [93]

High doses may lead to the K-hole phenomenon, characterized by extreme dissociation without loss of consciousness (Malhotra et al., 1996)

Markstedt K, Mantas A, Tournier I, Martnez vila H, Hgg D, Gatenholm P (2015) 3D bioprinting human chondrocytes with nanocellulose alginate bioink for cartilage tissue engineering applications