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Common side effects associated with NAD injections, particularly when administered intravenously, include: Injection site reactions : Pain, redness, or swelling at intramuscular injection sites Gastrointestinal symptoms : Nausea, cramping, or diarrhoea, especially with rapid IV infusion Flushing and warmth : Often described during or immediately after intravenous administration Chest tightness or discomfort : Typically mild and transient, but may be concerning for some patients Headache and dizziness : Reported occasionally, particularly with higher doses Infusion-specific risks include thrombophlebitis, extravasation, infection, air embolism, vasovagal reactions, and changes in blood pressure or heart rate

Patients and their families will have to weigh that benefit against the downsides, including regular IV infusions and potentially dangerous side effects like brain swelling

10.1007/s10529-011-0815-1 Xie Y, Chou L, Cutler A, Weimer B: DNA macroarray profiling of Lactococcus lactis subsp