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Growth rates and cumulative cell numbers were calculated using Microsoft Excel and the Prism 6.0.1 (GraphPad, USA) software

[138] Healthcare providers should consider dose reductions and extended dosing intervals for patients with documented liver disease

No other side effects were reported, this agrees with Watanabe and colleagues , who reported no adverse effects except mild erythema which disappeared on the fourth day without the need to discontinue the application of topical glutathione lotion

Calcitonin is a potent inducer of HEP expression, which may provide an interventional strategy to reverse FeRD 492