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The 2017 Neelakantan paper in Biochemistry characterised a fluorescent assay for direct real-time monitoring of NNMT enzymatic activity, providing the analytical foundation for inhibitor screening including 5-Amino-1MQ (PMID 28121423)

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At the level of adipose tissue, GIPR activation promotes fatty acid uptake during energy surplus and fatty acid release during energy deficit, effects that complement the appetite suppression driven by GLP-1R

As gastrin and its receptors are widely upregulated and involved in the development of gastrointestinal malignancy, attempts have been made to apply active vaccination using antigastrin-17 immunogen (G17DT) to raise the production of endogenous antibodies against gastrin for the purpose of counteracting the carcinogenic action of this hormone in GC (79)