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Patients assigned to tirzepatide showed a 20.9% BW loss after 36 weeks with an additional 5.5% reduction after 52 weeks, while those who switched to placebo experienced a 14% weight regain, confirming the findings from STEP 4 supporting the chronicity of obesity and the need for continuous treatment

10.1038/onc.2017.26 88 ZhangD

Finally, LPS measurement in serum or plasma, is elevated when the intestinal barrier is breached [35], but serum LPS is also increased during systemic inflammation and endotoxemia

This finding aligns with our previous results obtained from exosome chip data, further emphasising the core regulatory role of NCOA4 and TP53 in the cross-talk between ferroptosis and autophagy