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Symptomatic improvement when vitamin E was added to the treatment regimen was occasionally reported, but data for hepatic WD are mainly anecdotal because no rigorous studies have been conducted

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The largest review of antioxidants for female subfertility, a 2020 Cochrane systematic review covering 63 trials and 7,760 women, rated the evidence for any live-birth benefit as very low certainty (and a 2026 editorial note records that several of its included trials have since been retracted or placed under expression of concern, which does not change its cautious conclusion and, if anything, reinforces it)