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Contradictorily, high levels of serum HGF and overactive HGF/c-MET pathway in DLBCL patients have been also reported to be linked with unfavorable outcome in several studies [26, 27]

4.4.4 Anti-inflammatory effects in mental, stress and pain-related disorders Neuroinflammation is considered a pathogenic factor in the development of depression and anxiety (264), while flavonoids have been demonstrated to exert therapeutic effects on depression and anxiety by reducing neuroinflammation induced by microglia

Therefore, it has been proven that the mechanism responsible for cellular damage is associated with ROS

Zhou L, Too HP (2013) GDNF family ligand dependent STAT3 activation is mediated by specific alternatively spliced isoforms of GFR2 and RET