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NADPH bound at in a pocket of high hydrophilicity in the NADPH domain, at the interface with the FAD domain (Fig 2A, S4 Table)

Vitamin D deficiency affects the absorption of calcium in the intestine, which may reduce the concentration of calcium ions in the body, affect the transmission of TSH signal, and stimulate the compensatory secretion of more TSH in the pituitary gland (Babi Leko et al., 2023)