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Vital signs, adverse events, and rescue medication During the 60-minute in-hospital phase, the mean percentagewise increase in heart rate was 38% 22%, and the mean percentagewise decrease in blood pressure was 12% 12% (see the Supplemental Appendix Fig

doi: 10.1007/s00262-009-0776-6 273 Garca-VillalbaRGimnez-BastidaJACorts-MartnAvila-GlvezMToms-BarbernFASelmaMVet al

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Abnormal estrogen signaling through ER is a major driver of tumorigenesis in luminal A and luminal B breast cancers [4], as it promotes the proliferation of cancer cells by overexpressing cyclin D1 and c-Myc, both of which enable the tumors to bypass the G1/S checkpoint [5]