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administration of ketotifen can suppress the itching.23 We should bear in mind that localized itching can be a warning for the development of medullary tumors or tumors of the central nervous system,24,25 and so it is a relevant symptom in patients with NF1

10.1016/j.canlet.2018.05.017 Cancer Lett

[DOI] [PubMed] [Google Scholar] 23.Ward MS, Khoobehi A, Lavik EB, Langer R, Young MJ (2006) Neuroprotection of Retinal Ganglion Cells in DBA / 2J Mice With GDNF-Loaded Biodegradable Microspheres: 111