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GH is a counter-regulatory, insulin-antagonistic hormone: sustained elevation reduces peripheral insulin sensitivity, so the pancreas must secrete more insulin to hold blood glucose steady, and fasting glucose tends to drift upward

When GLP-1 agonists slow gastric emptying, large meals sit in the stomach longer, creating that heavy, nauseated feeling

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These advantages have made IN delivery ideal for urgent treatments like sedation, analgesia, opioid overdose, seizures and breakthrough pain relief in cancer patients (Doe-Simkins et al., 2009