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Similarly, a 2025 retrospective trial in 312 deficient children showed sublingual methylcobalamin (5001,000 mcg/day) boosted B12 from a median 172 ng/L to 438 ng/L in just 1.5 months, rivaling injections without needles

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Nitrous oxide (used in anaesthesia or misused recreationally) inactivates vitamin B12 and can precipitate or worsen neurological injury in patients with B12 deficiency

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