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Moreover, free radicals originating from tobacco smoke are implicated in the etiology of many subtypes of oral cancer, as they induce a state of chronic inflammation that is considered a common feature of oral carcinogenesis ( see , next section) [1, 22, 23, 34]

Time segments with the same direction, but different magnitude of change, were combined, and average monthly per cent change (AMPC) was calculated for the overall period, along with a p value, using Joinpoint regression program.15 16 To further simplify the presentation of results, time points detected by the total sales analysis were used in subsequent analyses, by flavour and products type, to test whether sales trends of these categories varied significantly at these time points

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