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These macrophages modulate the immune response not only through direct contact but also by secreting cytokines, which play roles in immunoregulation, tissue remodeling, and process of fibrosis (Yang et al., 2023)

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As noted in the CY 2025 PFS proposed rule (89 FR 61956), the reconciliation of a rebate amount, whether the regular reconciliation as set forth in 427.501(d)(1) or a discretionary reconciliation as set forth in 427.501(d)(2) discussed further below, will not create a separately payable and distinct rebate amount